New Valencia coach Gary Neville remains without a La Liga win after his side twice recovered from a goal down to rescue a fortunate 2-2 draw at home to Getafe on Saturday.
Struggling Rayo win at Valladolid after late penalty save
It was Messi's 56th converted penalty in La Liga and saw him draw level with Hugo Sanchez as the league's second-top penalty taker, behind record holder Cristiano Ronaldo on 61.
Cristiano Ronaldo struck twice as leaders Real Madrid subdued Eibar 4-0 on Saturday while Lionel Messi set a La Liga record of 253 goals with a hat-trick in second-placed Barcelona's 5-1 rout of Sevilla.
A round of Saturday's matches in Series A, La Liga and Bundesliga.
Atletico Madrid took a giant step towards the La Liga title
The Belgian forward came off the bench to make his Real debut in Saturday's 3-2 win over Levante, having had his start to life at the club hit by a thigh injury the day before the La Liga season began.
Real Madrid dropped points for the third time in seven games since Zinedine Zidane's return as they were held to a 0-0 draw away to Getafe in La Liga on Thursday, which harmed their neighbours' hopes of a top-four finish.
Barcelona look well set to wrap up the La Liga title.
News of all that's transpired on and off the football field.
Barcelona's rampant trio of Neymar, Luis Suarez and Lionel Messi all found the net at the weekend and unsung Leicester City found themselves in the record books when their England striker Jamie Vardy scored for the 11th straight game.
Barcelona's Lionel Messi was at the heart of another devastating attacking show.
Barcelona's Champions League last-16 second leg match with Napoli scheduled for March 18 will take place without spectators due to fears over the spread of the coronavirus, a club spokesman said on Tuesday. The match will take place at Camp Nou after a 1-1 draw in Napoli, but no supporters will be allowed to enter the stadium.
Atletico Madrid's Brazilian striker Diego Costa scored twice as they came from behind to beat Levante 3-2 at home on Saturday to go three points clear at the top of La Liga.
AC Milan, Villarreal and Nice reached the knockout stage of the Europa League after posting wins on Thursday in the penultimate round of the group stage.
'The pandemic has caused football to change a lot, and for the worse. You can see it in the matches, and I hope this all ends soon and we can get fans back into the stadiums and return to normality.'
Manchester City's quadruple bid remained intact as Ilkay Gundogan and Kevin de Bruyne secured a 2-0 win at Everton in their FA Cup quarter-final clash
England defender John Stones has been ruled out of their final two Euro 2016 qualifiers through injury, the FA said in a statement.
Messi stretched Barca's lead by finishing off a brilliant move with Luis Suarez in the 50th minute and the Uruguayan joined his close friend and strike partner on 15 league goals by robbing an Eibar defender and finishing inside the near post in the 68th.
Spain goalkeeper David de Gea made a rare error which led to his side drawing 1-1 at home to Switzerland in a World Cup warm-up friendly on Sunday which the hosts dominated but failed to make their superior possession count.
Champions Barcelona suffered their second defeat in three matches in La Liga on Saturday, with Michael Krohn-Dehli scoring and setting up another goal in a 2-1 victory for Sevilla.
Barcelona closed in on the La Liga title by thrashing local rivals Espanyol 5-0 on Sunday as Atletico Madrid dropped out of the race after losing 2-1 at Levante and Real Madrid beat Valencia 3-2.
It was a third successive 0-0 draw for United after a stalemate at Chelsea on Sunday and against Real Sociedad last Thursday which completed a 4-0 aggregate win over the Spanish side in the Europa League.
A senseless pitch invasion by Serbian fans in last month's Euro 2016 home qualifier against Albania has cost the Balkan nation dearly and the team fear the ramifications ahead of Friday's match against Denmark, Nemanja Matic said.
Images from the football matches played across Europe on Wednesday.
News of all that's transpired on and off the football field
A summary of Thursday's matches in Europe's second tier club football tournament
Chelsea, Bayern Munich, Real Madrid and Juventus consolidated their top-flight leads at the weekend while Paris St Germain proved too strong for Ligue 1 leaders Olympique Marseille.
Bayern Munich thrashed Bayer Leverkusen 5-1, while Barcelona came from behind to beat Valencia 3-1 in LaLiga at Camp Nou on Sunday.
News of all that's transpired on and off the football field
Holders Barcelona crashed out of the Champions League after being stifled by a brilliantly well-organised Atletico Madrid.
A second-string Spain celebrated coach Vicente del Bosque's two-year contract extension with a 2-1 away win over Equatorial Guinea in a friendly on Saturday that was marred by an injury to Xabi Alonso.
Neymar scored the opener to continue his rich vein of form as 10-man Barcelona won a one-sided La Liga derby against Espanyol.
Spain coach Vicente del Bosque has called Atletico Madrid's Brazil-born forward Diego Costa into his squad for the first time for this month's friendlies away to Equatorial Guinea and South Africa.
Underlying tensions mean Luis Enrique will not be remembered with the same reverence as Pep Guardiola, even though he has delivered a similar trophy haul.
News of all that's transpired on and off the football field
'I feel as confident and motivated as at the beginning. I can't control rumours, but I still have faith'
Key head-to-head battles in Saturday's "Clasico" between Real Madrid and Barcelona at the Bernabeu stadium (1600 GMT)
Barcelona suffered a first home defeat of the season when they lost 3-2 against Valencia after finishing with 10 men in La Liga on Saturday, leaving the door open for Madrid rivals Atletico and Real to move above them.
Barcelona dropped their first points of the La Liga season as their star-studded forward line misfired in a 0-0 draw away to Malaga on Wednesday.
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